CENBIMO S.L

INTRODUCTION

Calcitonin is a peptide of 32 amino acids and 3.4 kDa produced by the thyroid parafollicular cells or C cells.

Calcitonin is coded by a gene named calcitonin gene-related peptide (CGRP) that also includes the code for a peptide related to calcitonin but with a completely different physiological function. The production of one or the other peptide is due to a splicing alternative.

The principle physiological function of this hormone is to produce a decrease in the blood concentration of calcium and phosphates producing an incorporation of these ions into the bones.

The tumoral degeneration of C cells produces a Thyroid Medullary Carcinoma also known as Thyroid Parafollicular Carcinoma. Approximately 70% of Thyroid Medullary Carcinomas are sporadic and approximately 30% are familial and inheritable within the context of MEN 2A.

MEN 2A patients can also demonstrate C cell hyperplasia before developing a tumor.

INTENDED USE

For use in In Vitro Diagnosis.

Histosonda Calcitonin is useful for the diagnosis of Thyroid Medullary Carcinomas and C cell Hyperplasia.

WARNINGS AND PRECAUTIONS

Histosonda Calctionin has been designed for professional use in In Vitro Diagnosis and must be manipulated by qualified and accordingly trained personnel.

In order to obtain the best results, the instructions contained in the manual must be followed. Any change to the indicated temperatures, times or any other step of the process can lead to poor results.

KIT COMPONENTS

The kit includes 20 single test tubes of lyophilized Histosonda Calcitonin.

Histosonda Calcitonin consists of two segments of single-stranded DNA complementary to expressed RNA with lengths of 166 and 142 nucleotides.