CENBIMO S.L

INTRODUCTION

VIP is produced by some of the hipothalamic neurons and by the intestinal mienteric plexus neurons.

VIP producing cells do not exist in the pancreas but surprisingly, there exist pancreatic insular tumors that produce VIP and are thus named VIPOMAS. These tumors are situated in the tail of the pancreas and also in the duodenum in children. Some pheochromocytomas have also been described in the literature as producing this peptide.

Patients with VIPOMAS demonstrate a syndrome characterized by watery diarrhea, hypokalemia and achlorhydria, known as Verner-Morrisson Syndrome.

Approximately 80% of VIPOMAS have a malignant behavior.

HISTOSONDA VIP consists of a single stranded DNA fragment with a length of 533 nucleotides.

INTENDED USE

For use in In Vitro Diagnosis.

Histosonda Vasoactive Intestinal Peptide is useful for the study and classification of neuroendocrine tumors of the pancreas and digestive apparatus and their metastases even in an absence of a clinically evident Endocrine Syndrome.

WARNINGS AND PRECAUTIONS

Histosonda Vasoactive Intestinal Peptide has been designed for use in In Vitro Diagnosis for professional use and must be manipulated by qualified and accordingly trained personnel.

In order to obtain the best results, the instructions contained in the manual must be followed. Any change of the indicated temperatures or times, or of any other step of the process can lead to poor results.

KIT COMPONENTS

The kit includes 20 single test tubes of lyophilized Histosonda Vasoactive Intestinal Peptide.

Histosonda Vasoactive Intestinal Peptide consists of a single stranded DNA fragment with a length of 533 nucleotides.