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HISTOSONDA® GASTRIN

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GastrinINTRODUCTION

Gastrin is a peptide fundamentally produced by neuroendocrine cells known as G cells situated in the bottom of the gastric antrum crypts. The principle mission of these cells is to stimulate the secretion of hydrogen chloride in the mucosal parietal cells of the gastric body.

There are G cell tumors which exist in the pancreas and duodenum even though these cells are not normally found in either of these organs.

Tumors that secrete gastrin are known as gastrinomas and more than 50% of these are malignant. These tumors can be associated with Zollinger-Ellison syndrome.

Duodenal gastrinomas are frequently associated with MEN1 syndrome and are usually of a small size. They are generally unapparent although they metastatasize early in the lymph node regions and the metastasis is usually a larger size than that of the tumor of origin.

The pancreatic gastrinomas are less frequently associated with MEN 1 and they metastatasize principally in the liver.

The regulation of hydrochloric acid secretion in the stomach is maintained by a feedback response related to gastrin. For this reason hypergastrinemia and hyperplasia of the G cells is frequently observed in patients with fundamentally autoimmune-type atrophic gastritis.

INTENDED USE

For use in In Vitro Diagnosis.

Histosonda Gastrin is useful for the diagnosis of neuroendocrine tumors producing gastrin and validation of G cell hyperplasias in the stomach.

WARNINGS AND PRECAUTIONS

Histosonda Gastrin has been designed for professional use in In Vitro Diagnosis and must be manipulated by qualified and accordingly trained personnel. In order to obtain the best results, the instructions contained in the manual must be followed. Any change

to the indicated temperatures, times or any other step of the process can lead to poor results.

KIT COMPONENTS

The kit includes 20 single test tubes of lyophilized Histosonda Gastrin.

Histosonda Gastrin consists of a single stranded DNA fragment with a length of 343 nucleotides targeted against gastrin mRNA.